The Nuclear Receptor-Mediated Endocrine Activity model provides a qualitative prediction of 12 classical nuclear receptor-mediated endocrine disruptions, including Androgen Receptor (AR), Estrogen Receptor α/β (ERα/β), Glucocorticoid Receptor (GR), Mineralocorticoid Receptor (MR), Progesterone Receptor (PR), Retinoic Acid Receptor α/β/γ (RARα/β/γ), Thyroid Hormone Receptor α/β (TRα/β), and Vitamin D Receptor (VDR).