The application relies on a battery of QSAR models, combined in a workflow resulting in a final prediction for the P, B and T property of each compound, provided with a reliability value. These predictions are then transformed into normalized scores, which are combined into a global PBT score, useful for screening and ranking purposes.

Download PROMETHEUS Application

The application is developed in Java and can be run on every platform supporting the Java Runtime Environment, version 7 (see for further details).

PROMETHEUS has been developed under a grant by Umwelt Bundesamt (UBA). UBA holds the intellectual property of the software and of the methodology hereby implemented. UBA releases the software under a GPL 3 (GNU General Public License version 3) license.

Developed by

  • Istituto di Ricerche Farmacologiche Mario Negri - IRCCS
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  • KODE chemo informatics logo
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