The Prometheus application provides an overall PBT (persistence, bio-concentration, toxicity) assessment based on QSAR modelling, combined in a final score useful for ranking compounds.

It is based on the conceptual scheme developed within the Prometheus project of the UBA (Umwelt Bundesamt, German Federal Environment Agency) and fully reported in the following publication:

F Pizzo, A Lombardo, A Manganaro, C Cappelli, M Petoumenou, F Albanese, A Roncaglioni, M Brandt, E Benfenati, “Integrated in silico strategy for PBT assessment and prioritization under REACH”, Environmental Research 151, 478-492