VERA Alerts and VERA Entities is an open-access software for chemical read-across to assess the (eco)toxicity of substances.
Within the EC-funded LIFE project CONCERT REACH and imi-PREMIER, the new open-access software for chemical read-across VERA has been developed. Read-across applies the principle of similarity to identify the most similar substances to represent a given target substance in data-poor situations. However, differences between the target and the source substances exist. VERA (Virtual Extensive Read-Across) provides a means to assess the similarity between chemicals using structural alerts specific to the property, pre-defined molecular groups and structural similarity. The software finds the most similar compounds with a certain feature e.g. structural alerts and molecular groups and provides clusters of similar substances while comparing these similar substances within different clusters.
This work was financially supported by PREMIER (Prioritisation and Risk Evaluation of Medicines in the EnviRonment). PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under Grant Agreement No. 875508. This Joint Undertaking receives support from the European Union’s Horizon 2020 Research and Innovation Programme and the European Federation of Pharmaceutical Industries and Associations.
Download VERA Application
VERA is a JAVA application that works on Windows operating system that supporting Java. Java 11 or higher is required. You can download OpenJDK installers from https://jdk.java.net/ or follow the instructions available on the OpenJDK website .
Download and unpack the zipped file. To start the application, just move to the unzipped folder and run the file VERA_entities.exe with the Java Runtime Environment (JRE). On most systems, it is enough to double-click it.
